The nervous system has two components namely the central nervous system and peripheral nervous system. The peripheral system consists of nerves and ganglia that exist outside the spinal cord and brain. It connects your limbs and organs to the central nervous system. Unfortunately, damage to the peripheral nerves is possible.

The technical name for this damage is neuropathy. It results in a feeling of weakness, numbness, or pain in the affected area. Treating neuropathy involves managing its symptoms so that life becomes as comfortable as possible for the affected person. Here are the 4 most popular neuropathy treatments to try.

The 4 Most Popular Neuropathy Treatments


Antidepressants refer to a class of drugs used for the treatment of major depressive disorders. These disorders include obsessive-compulsive disorder and social anxiety disorder. Antidepressants are also useful in the treatment of other conditions including nerve pain. Researchers studying neuropathy recommend these drugs as the foremost treatment option when it comes to this condition. 

Studies have also shown that tricyclics, which are a category of antidepressants, provide the most significant relief for patients who have neuropathy. These antidepressants dampen the pain signals that peripheral nerves send to the central nervous system. Doing so reduces the level of pain that one would feel in the affected area.


Anticonvulsants refer to a class of drugs mostly used for the treatment of epileptic seizures. Nowadays, psychiatrists prescribe them for the management of bipolar disorder or borderline personality disorder. The use of these drugs is also extending into the treatment of neuropathic pain.

Recently, Tremont-Lukats revealed that similarities exist between pathophysiological phenomena in epileptic and neuropathic patients. Therefore, using anticonvulsant drugs in the treatment of neuropathic pain is justifiable because the drugs act on the same pathophysiological phenomena. Dr. Tremont-Lukats, a renowned neurologist, identified Gabapentin as the most effective anticonvulsant for this purpose followed closely by Carbamazepine. His study concluded that anticonvulsants treat neuropathy by decreasing conductance that occurs in Na+ channels leading to the inhibition of ectopic discharges.

3. OTC Pain Killers

Did you know that OTC Painkillers are the most frequently bought painkillers in the country?

Unfortunately, many people abuse these drugs instead of using them for the correct purpose. For example, using them to treat neuropathic pain is an excellent idea. More specifically, these painkillers treat your pain by reducing the production of prostaglandin in the body. This substance facilitates the sending of messages to your brain. Reducing it means you will not feel as much neuropathic pain as you would have felt without it.

Go for acetaminophen or non-steroidal anti-inflammatory painkillers because they have additional uses. For example, apart from treating neuropathy, acetaminophen reduces your fever while non-steroidal anti-inflammatory drugs treat swellings and fever.

4.  Supplements

It is worth noting that these treatments for neuropathic pain lead to significant side effects. For example, antidepressants often cause drowsiness, constipation, and a decreased level of appetite. Developing liver dysfunction is also possible if you use anticonvulsants. Neuropathic patients have sought alternative ways of dealing with this pain for many years. They are seeking alternatives because they want to avoid the side effects that come with antidepressants, anticonvulsants, and OTC painkillers.

Today, neuropathy supplements are available as a viable alternative to these drugs. These supplements treat neuropathy by ensuring that peripheral nerves receive the required nutrients. Check out to learn more about them and other treatment options for this condition.

(Last Updated On: January 28, 2021)

A senior academic researcher, reviewer, and editor, Dr. Declan Pouros is also an internationally accredited psychotherapist. He earned his PhD in Psychological Counseling and Guidance, and in the years since, he has taught in the Department of Psychological Counseling and Guidance himself.He has also authored papers that have gone on to appear in such world-renowned journals as the European Journal of Psychological Assessment, Psychological Reports, the Scandinavian Journal of Psychology. Asia Pacific Psychiatry, and Computers in Human Behaviour.